Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR001472 Bipartite nuclear localization signal	1778	7038	21	IPR002110 Ankyrin	111	970
2	IPR000694 Proline-rich region	658	3763	22	IPR002048 Calcium-binding EF-hand	109	488
3	IPR000719 Protein kinase	585	3764	23	IPR003961 Fibronectin, type III	105	530
4	IPR001687 ATP/GTP-binding site motif A (P-loop)	517	2324	24	IPR002126 Cadherin	94	1901
5	IPR000276 Rhodopsin-like GPCR superfamily	431	5328	25	IPR000219 DH domain	93	633
6	IPR000504 RNA-binding region RNP-1 (RNA recognition motif)	237	1445	26	IPR000047 Helix-turn-helix motif, lambda-like repressor	93	780
7	IPR000345 Cytochrome c heme-binding site	235	2501	27	IPR001452 SH3 domain	91	581
8	IPR007087 Zn-finger, C2H2 type	205	1990	28	IPR000048 IQ calmodulin-binding region	91	1112
9	IPR001680 G-protein beta WD-40 repeat	183	1779	29	IPR001064 Beta and gamma crystallin	81	587
10	IPR000008 C2 domain	178	1628	30	IPR000198 RhoGAP domain	81	405
11	IPR001356 Homeobox	164	896	31	IPR001622 K+ channel, pore region	80	1004
12	IPR001230 Prenyl group binding site (CAAX box)	159	683	32	IPR001254 Serine protease, trypsin family	77	451
13	IPR000210 BTB/POZ domain	152	1404	33	IPR001849 Pleckstrin-like	75	191
14	IPR001092 Basic helix-loop-helix dimerization domain bHLH	137	462	34	IPR001128 Cytochrome P450	74	988
15	IPR001841 Zn-finger, RING	134	369	35	IPR000169 Eukaryotic thiol (cysteine) protease	74	573
16	IPR001611 Leucine-rich repeat	129	878	36	IPR000379 Esterase/lipase/thioesterase, active site	70	307
17	IPR007110 Immunoglobulin-like	123	227	37	IPR001993 Mitochondrial substrate carrier	69	522
18	IPR001478 PDZ/DHR/GLGF domain	112	442	38	IPR000242 Tyrosine specific protein phosphatase	65	828
19	IPR001440 TPR repeat	112	1036	39	IPR000175 Sodium:neurotransmitter symporter	63	474
20	IPR000152 Aspartic acid and asparagine hydroxylation site	111	4019	40	IPR000051 SAM (and some other nucleotide) binding motif	59	141

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