Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR000694 Proline-rich region	992	15830	21	IPR000048 IQ calmodulin-binding region	83	2772
2	IPR000276 Rhodopsin-like GPCR superfamily	556	11007	22	IPR000315 Zinc finger, B-box	76	2284
3	IPR000719 Protein kinase, core	316	8037	23	IPR003598 Immunoglobulin subtype 2	73	1559
4	IPR000504 RNA recognition motif, RNP-1	207	2782	24	IPR000372 Leucine-rich repeat, cysteine-rich flanking region, N-terminal	72	2048
5	IPR001909 KRAB box	200	9957	25	IPR001254 Peptidase S1 and S6, chymotrypsin/Hap	67	804
6	IPR000533 Tropomyosin	191	3552	26	IPR000108 Neutrophil cytosol factor 2	66	3130
7	IPR001680 WD40 repeat	184	4759	27	IPR007086 Zinc finger, C2H2-subtype	65	1694
8	IPR001781 LIM, zinc-binding	171	10184	28	IPR000742 EGF-like, type 3	62	3522
9	IPR000210 BTB/POZ-like	164	4261	29	IPR001092 Basic helix-loop-helix dimerisation region bHLH	61	415
10	IPR000104 Antifreeze protein, type I	149	2994	30	IPR000357 HEAT	60	538
11	IPR001841 Zinc finger, RING-type	134	1206	31	IPR001128 Cytochrome P450	60	1898
12	IPR000047 Helix-turn-helix motif, lambda-like repressor	134	2309	32	IPR001304 C-type lectin	59	749
13	IPR003596 Immunoglobulin V-set, subgroup	130	3792	33	IPR002126 Cadherin	56	3802
14	IPR001806 Ras GTPase	125	2018	34	IPR000637 HMG-I and HMG-Y, DNA-binding	55	1091
15	IPR000008 C2 calcium-dependent membrane targeting	123	3897	35	IPR000198 RhoGAP	54	929
16	IPR002110 Ankyrin	109	3420	36	IPR000219 DH	53	1420
17	IPR001611 Leucine-rich repeat	92	1664	37	IPR001478 PDZ/DHR/GLGF	51	1232
18	IPR000152 Aspartic acid and asparagine hydroxylation site	90	12428	38	IPR009443 Nuclear pore complex interacting	51	77
19	IPR002048 Calcium-binding EF-hand	90	1147	39	IPR001664 Intermediate filament protein	50	519
20	IPR001440 Tetratricopeptide TPR_1	83	2591	40	IPR000225 Armadillo	50	1032

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