Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR000276 Rhodopsin-like GPCR superfamily	1220	22164	21	IPR001128 Cytochrome P450	82	4083
2	IPR000694 Proline-rich region	747	17282	22	IPR001440 Tetratricopeptide TPR_1	81	2477
3	IPR000719 Protein kinase	336	8887	23	IPR000048 IQ calmodulin-binding region	77	3256
4	IPR003596 Immunoglobulin V-set, subgroup	258	4710	24	IPR000104 Antifreeze protein, type I	75	1231
5	IPR000504 RNA-binding region RNP-1 (RNA recognition motif)	222	3028	25	IPR000108 Neutrophil cytosol factor 2	73	4935
6	IPR001781 LIM, zinc-binding	206	78290	26	IPR000068 Extracellular calcium-sensing receptor	71	3890
7	IPR001909 KRAB box	189	52695	27	IPR001092 Basic helix-loop-helix dimerisation region bHLH	70	353
8	IPR001680 WD-40 repeat	183	4776	28	IPR000169 Peptidase, cysteine peptidase active site	66	2409
9	IPR000210 BTB	171	5109	29	IPR001478 PDZ/DHR/GLGF	64	1170
10	IPR000533 Tropomyosin	168	2340	30	IPR000357 HEAT	63	569
11	IPR001841 Zinc finger, RING-type	134	1123	31	IPR007086 Zinc finger, C2H2-subtype	59	2303
12	IPR001806 Ras GTPase	124	1859	32	IPR001254 Peptidase S1 and S6, chymotrypsin/Hap	59	845
13	IPR003598 Immunoglobulin subtype 2	124	2176	33	IPR000372 Leucine-rich repeat, cysteine-rich flanking region, N-terminal	58	1975
14	IPR000047 Helix-turn-helix motif, lambda-like repressor	120	1906	34	IPR000742 EGF-like, type 3	57	2788
15	IPR000008 C2 calcium-dependent membrane targeting	119	3472	35	IPR001222 Transcription factor TFIIS	57	25566
16	IPR000315 Zinc finger, B-box	105	5066	36	IPR000198 RhoGAP	56	830
17	IPR002048 Calcium-binding EF-hand	102	926	37	IPR000467 D111/G-patch	55	392
18	IPR002110 Ankyrin	96	2901	38	IPR000306 Zinc finger, FYVE-type	54	11278
19	IPR001611 Leucine-rich repeat	95	1766	39	IPR000219 DH	54	1315
20	IPR000152 Aspartic acid and asparagine hydroxylation site	88	14734	40	IPR001993 Mitochondrial substrate carrier	54	1048

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