Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR000694 Proline-rich region	983	15648	21	IPR000152 Aspartic acid and asparagine hydroxylation site	82	11366
2	IPR000276 Rhodopsin-like GPCR superfamily	544	11379	22	IPR000048 IQ calmodulin-binding region	78	3438
3	IPR000719 Protein kinase	335	7525	23	IPR000372 Leucine-rich repeat, cysteine-rich flanking region, N-terminal	74	2570
4	IPR003596 Immunoglobulin V-type	240	3605	24	IPR000315 Zinc finger, B-box	72	2735
5	IPR000504 RNA-binding region RNP-1 (RNA recognition motif)	237	3229	25	IPR001254 Peptidase S1 and S6, chymotrypsin/Hap	72	865
6	IPR001909 KRAB box	200	12206	26	IPR001128 Cytochrome P450	72	2387
7	IPR000533 Tropomyosin	197	3086	27	IPR000108 Neutrophil cytosol factor 2	71	3106
8	IPR001781 LIM, zinc-binding	178	15310	28	IPR001092 Basic helix-loop-helix dimerisation region bHLH	71	369
9	IPR001680 WD-40 repeat	175	4152	29	IPR003598 Immunoglobulin C2 type	68	1491
10	IPR000210 BTB	162	4258	30	IPR000357 HEAT	67	462
11	IPR001841 Zinc finger, RING-type	140	1344	31	IPR007086 Zinc finger, C2H2-subtype	66	1934
12	IPR000047 Helix-turn-helix motif, lambda-like repressor	135	2129	32	IPR000742 EGF-like, type 3	63	3051
13	IPR000104 Antifreeze protein, type I	134	2910	33	IPR001478 PDZ/DHR/GLGF	60	999
14	IPR001806 Ras GTPase	132	1951	34	IPR000379 Esterase/lipase/thioesterase	60	576
15	IPR000008 C2	130	3279	35	IPR000198 RhoGAP	57	977
16	IPR002110 Ankyrin	105	3026	36	IPR001304 C-type lectin	56	719
17	IPR002048 Calcium-binding EF-hand	102	1022	37	IPR000169 Peptidase, cysteine peptidase active site	56	2261
18	IPR001611 Leucine-rich repeat	96	1892	38	IPR000637 HMG-I and HMG-Y, DNA-binding	55	1014
19	IPR001664 Intermediate filament protein	91	759	39	IPR000626 Ubiquitin	54	451
20	IPR001440 Tetratricopeptide TPR_1	85	2660	40	IPR002130 Peptidyl-prolyl cis-trans isomerase, cyclophilin type	54	396

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